Cheesecake Files: The ICare-Acute Coronary Syndrome (heart attack) study

Hundreds of nurses, Emergency Department doctors, Cardiologists and other specialists, laboratory staff, administrators and managers from every hospital in New Zealand with an emergency department have come together to implement new, effective, and safe pathways for patients who think they may be having a heart attack.  Today, Dr Martin Than (CDHB, Emergency Department) presented to the American Heart Association results of our research into the national implementation of clinical pathways that incorporate an accelerated diagnostic protocol (ADP) for patients with possible heart attacks.  Simultaneously, a paper detailing that research is appearing in the academic journal Circulation.

The headlines, are that in the 7 hospitals we monitored (representing about 1/3rd of all ED admissions in NZ a year), there was a more than two fold increase in the numbers of patients who were safely discharged from the ED within 6 hours of arrival and told “It’s OK, you are not having a heart attack”.

Improving Care processes for patients with a possible heart attack.

Why is this important?

About 65,000 of the 1 million presentations to EDs each year in New Zealand are for patients whom the attending doctors think may be having a heart attack.  However, only 10-15% of those 65,000 are actually having a heart attack.  The traditional approach to assessment is long, drawn out, involves many resources, and means thousands of people are admitted into a hospital ward even thought it turns out they are not having a heart attack.  Of course, this means that they and their families have a very uncomfortable 24 hours or so wondering what is going on.  So, any method that safely helps to reassure and return home early some of those patients is a good thing.

What is a clinical pathway?

A clinical pathway is a written document based on best practice guidelines that is used by physicians to manage the course of care and treatment of patients with a particular condition or possible condition.  It is intended to standardise and set out the time frame for investigation and treatment within a particular health care setting – so it must take into account the resources available for a particular hospital.   For example, each hospital must document how a patient is assessed and if, for example, they are assessed within the ED as having a high-risk of a heart attack, where they must go.  In a large metropolitan hospital, this may mean simply passing them into the care of the cardiology department.  In a smaller setting like Taupo, where there is  no cardiology department, it may mean documenting when and how they are transported to Rotorua or Waikato hospital.

What is an accelerated diagnostic protocol?

An accelerated diagnostic protocol (ADP) is a component of the clinical pathway that enables the ED doctors to more rapidly and consistently make decisions about where to send the patient.  In all cases in New Zealand the ADPs for evaluating suspected heart attacks have 3 main components: (i) an immediate measurement of the electrical activity of the heart (an ECG), (ii) an immediate blood sample to look for the concentration of a marker of heart muscle damage called troponin, and a second sample 2 or 3 hours later, and (iii) a risk score based on demographics, prior history or heart conditions, smoking etc., and the nature of the pain (ie where it hurts and does it hurt when someone pushes on the chest, or when the patient takes deep breaths etc).   Importantly, these components enable a more rapid assessment of patients than traditionally and, in-particularly, enable patients to be rapidly risk stratified into low-risk, intermediate risk, and high-risk groups.  Usually the low-risk patients can be sent home.

What was done?

The Ministry of Health asked every ED to put in place a pathway.  Over an ~18 month period, a series of meetings were held at each hospital which were led by Dr Than, the clinical lead physician for the project.  Critically, at each meeting there were multiple members of the ED (doctors and nurses), cardiology, general wards, laboratory staff, and hospital administrators.  The evidence for different ADPs was presented.  Each hospital had to assess this evidence themselves and decide on the particularly ADP they would use.  Potential barriers to implementation and possible solutions were discussed.  Critically, champions for different aspects of the pathway implementation process were identified in each hospital.  These people led the process internally.

Oversight of the implementation was an adhoc advisory board put together by the Ministry of Health and with MoH officials, Dr Than, Cardiologists, and myself.

The Improving Care processes for patients with suspected Acute Coronary Syndrome (ICare-ACS) study was a Health Research Council sponsored study with co-sponsorship of staff time by participating hospitals.  Its goal was to measure any changes in each hospital to the proportions of patients who were being discharged home from ED early and to check whether they were being discharged safely (ie to check that there were not people with heart attacks were being sent home).  Dr Than and I co-led this project, but there were many involved who not only set up the pathways in each of the 7 participating study hospitals, but who also helped with attaining the data for me to crunch.

What were the study results?

In the pre-clinical pathway implementation phase (6 months for each hospital) there were 11,529 patients assessed for possible heart attack. Overall, 8.3% of them were sent home within 6 hours of arrival (we used 6 hours because this is a national target for having patients leave the ED).  The proportions of patients sent home varied considerably between hospitals – from 2.7% to 37.7%.  Of those sent home early, a very small proportion (0.52%) had what we call a major adverse event (eg a heart attack, a cardiac arrest, or death for any reason) within 30 days.  This is actually a very good number (it is practically impossible to be 0%).

We monitored each hospital for at least 5 months after pathway implementation and a median of 10.6 months.  Of the 19,803 patients, 18.4% were sent home within 6 hours of arrival.  ie the pathway more than doubled the number of patients who were sent home early.  Importantly, all 7 of the hospitals sent more patients home earlier.  The actual percentages sent home in each hospital still varied, showing there are more further improvements to be made in some hospital than others.  Very importantly, the rate of major adverse events in those sent home remained very low (0.44%).  Indeed, when we looked in detail at the few adverse events, in most cases there was a deviation from the local clinical pathway.  This suggests that some ongoing education and “embedding in” of the pathways may improve safety even more.

The study also showed that amongst all patients without a heart attack the implementation of the pathway reduced the median length of stay in hospital by nearly 3 hours.  Using crude numbers for the cost of an acute event in a hospital I estimate that this is a saving to the health system of $9.5Million per year.  These types are calculations are difficult and full of assumptions, nevertheless, I can be confident that the true savings are in the millions (pst… Government… I wouldn’t mind a fraction of this saving to carry on research please).

How did this come about?

This study and the pathway implementation is the result of a decade long series of studies in Christchurch hospital and some international studies, particularly with colleagues in Brisbane.  These studies have involved ED staff, cardiologists, research nurses, University of Otago academics (particularly those in the Christchurch Heart Institute) and many others.  They began with an international onbservational study which measured troponin concentrations at earlier than normal time points to see whether they gave information that would enable earlier discharge of some patients.  This was followed by the world’s first randomised trial of an ADP verse standard (then) practice.  That showed that the ADP resulted in more patients being safely sent home.  It was immediately adopted as standard practice in Christchurch.  The ADP was refined with a more “fit for purpose” risk assessment tool (called EDACS – developed locally and with collaboration of colleagues in Brisbane).  The EDACS protocol was then compared to the previous protocol (called ADAPT) in a second randomised trial.  It was at least as good with potential for discharging safely even more patients.  It is currently standard practice in Christchurch.

As a consequence of the Christchurch work, the Ministry of Health said, effectively,  ‘great, we want all of New Zealand to adopt a similar approach’, and the rest, as they say, is history.  Now, all EDs have a clinical pathway in place, all use an evidence based ADP – two use the ADAPT and all the rest use EDACS with one exception which uses a more ‘troponin centric’ approach (still evidence based) which I won’t go into here.  Meanwhile, all of Queensland has adopted the ADAPT approach and we know of many individual hospitals in Australia, Europe and Iran (yes) which have adopted EDACS.

Other help

As mentioned already, the Health Research Council and the Ministry of Health along with all those medical professionals were integral to getting to where we are today.  Also integral, were all those patients who in the randomised trials agreed to participate.  Medical research is build on the generosity of the patient volunteer.  Behind the scenes is our research manager, Alieke, who ensures doctors run on time.  Finally, I am very fortunate to be the recipient of a research fellowship that enables me to do what I do.  I thank my sponsors, the Emergency Care Foundation, Canterbury Medical Research Foundation, and Canterbury District Health Board.  Some of the earlier work has also been done in part with my University of Otago Christchurch hat on.  Thank you all.


Half a million Kiwis suddenly have high blood pressure

At 10am 14 November 2017 NZST millions of people around the world suddenly had high blood pressure. This will come as a shock to many and may precipitate a crisis in hand wringing and other odd behaviour, like over medication and jogging.

The American Heart Association and American College of Cardiology have just announced a redefinition of High blood pressure.

High blood pressure is now defined as readings of 130 mm Hg and higher for the systolic blood pressure measurement, or readings of 80 and higher for the diastolic measurement. That is a change from the old definition of 140/90 and higher, reflecting complications that can occur at those lower numbers. (link)

Announced at the annual American Heart Association conference, this is bound to cause some consternation.  It shifts 14% of the US adult population into the “High blood pressure” category and I estimate that it will do something similar for the NZ population meaning half a million New Zealanders who didn’t have High blood pressure at 9am now have high blood pressure (assuming NZ cardiologists follow their US colleagues).

While this is, of course, absurd.  It also highlights the seriousness with which the cardiologists take elevated blood pressure – maybe we all should take it a bit more seriously, perhaps park the care further from work and walk a little (likely to be cheaper too).

Have you got high blood pressure. (c) American Heart Association


Performance Based Research Fund: a net zero sum game

Throughout the land more than 7000 academics are awake night after night and suffering.  They are scrambling to gather evidence of just how great they have performed over the last six years. A conscientious bunch, they perform this task with their usual attention to detail and desire to impress (I didn’t say they were modest!).  Ostensibly, this exercise is so that their institutions can get a greater piece of the Government research fund pie – the Performance Based Research Fund (PBRF).  According to the Tertiary Education Commission PBRF is “a performance-based funding system to encourage excellent research in New Zealand’s degree-granting organisations.”  It may well do that, but, I contend, only by deception.

In what follows I am only concerned with the Quality Evaluation part of PBRF – that’s the bit that is related to the quality of the Evidence Portfolio (EP) provided by each academic. The data is all taken from the reports published after each funding round (available on the TEC website).

In 2012 the total funding allocated on the basis of EPs was $157 million with nearly 97% of it allocated to the country’s 8 universities.  This total amount is set by Government fiat and, here is the important point, in no way depends on the quality of the Evidence Portfolios provided by those 7000+ academic staff.   In other words, from a funding perspective, the PBRF Quality Evaluation round is a net zero sum game.

PBRF Quality Evaluation is really a competition between degree granting institutions.  I find this strange given the Government has been trying to encourage collaboration between institutions through funding of National Science Challenges, nevertheless a competition it is.

In the table we see the results of the Quality Evaluation for the previous three funding rounds ( 2003, 2006 and 2012).  Not surprisingly, the larger universities get a larger slice of the pie.  The pie is divvied up according to a formula that is based on a weighting for each academic according to how their research has been evaluated (basically A, B or C), multiplied by a weighting according to their research area (eg law and arts are weighted lower than most sciences, and engineering and medicine are weighted the highest), multiplied by the full time equivalent status of the academic.   In theory, therefore, an institution may influence their proportion of funding by (1) employing more academics – but this costs more money of course, so may be defeating, (2) increasing the proportions of academics in the higher weighted disciplines (some may argue this is happening), and (3) increase the numbers of staff with the higher grades.  I will leave it to others to comment on (1) or (2) if there is evidence for them.  However (3) is the apparent focus of all the activity I hear about at my institution.   There are multiple emails and calls to attend seminars, update publication lists, and to begin preparing an Evidence Portfolio.  Indeed, in my university we had a “dry run” a couple of years ago, and it is all happening again.

Now, I come to the bit where I probably need an economist (it is my hope that this post may influence one to take up this matter more).  Because it is a net-zero sum game, what matters is a cost-benefit analysis for individual institutions.  That is, what does it cost the institutions to gather EPs compared to what financial gain is there from the PBRF Quality Evaluation fund?  If we look at the 20012-2006 column we see the change in percentage for each institution.  The University of Auckland for example increased its share of the pie by 1.3% of the pie.  This equates to a little under $2M a year.  As the evaluations happen only every 6 years we may say that Auckland gained nearly $12M.  What was the cost? How many staff for how long were involved?   As there are nearly 2000 staff submitting EPs from Auckland another way of looking at this is that the net effect of the 2012 Quality Evaluation round was a gain of less than $6000 per academic staff member over 6 years.  How much less is unknown.

The University of Otago had a loss in 2012 compared with 2006.  Was this because it performed worse – not at all, indeed Otago increased how many staff and the proportion of staff that were in the “A” category and in the “B” category. This suggests improved, not worsened, performance.  I think that Otago’s loss was simply due to the net zero sum game.

Much more could be said and questions asked about the Quality Evaluation, such as what is the cost of the over 300 assessors of the more than 7000 EPs?  Or perhaps I could go on about the terrible use of metrics we are being encouraged to use as evidence of the importance of the papers we’ve published.  But, I will spare you that rant, and leave my fellow academics with the thought – you have been deceived, PBRF Evidence portfolios are an inefficient and costly exercise which will make little to no difference to your institution. 

Flourish with change

Newshub decided to do an “AI” piece today. Expect much more of this kind of “filler” piece. They will go thus… “X says AI will take all our jobs, Y says AI will save us.” These pieces are about as well informed and informing as a lump of 4×2 – good for propping up a slow news day, but not much else. The “more compassionate and moral than NZers” message (which comes from Y) type statement that was made is utter nonsense. AI is just a name we give to the software of machines – AI don’t have compassion or morals. If they appear too, that is simply because they are reflecting the data we feed them… human data with all its flaws.
Yes, there is change coming because of this technology. In the past we have been particularly poor at predicting what the future will look like & I think this time the possibilities are far too numerous and complex for us to predict what will be.  Statements like “30-50% of people will lose their jobs” (said X) are simply guesses because there is no precedent on which to base the numbers. All the reports talk about truck drivers and accountants loosing jobs and not a lot else. They are shallow – and probably necessarily so – because we just can’t anticipate what creative people may come up with for this technology.  Having said that, I must admit I just am not sure what to advise my children (as if they’d take it).  Should they all learn to code? Maybe not, as most interaction with machines may not be via coding languages. Should they become artisans for niche markets where the technology doesn’t penetrate?  Maybe for some, but not for all.  I think that perhaps the best we can do is to encourage what enhances creativity and resilience to, or even better a flourishing with, change. It is my hope that flourish with change will become the mantra not just the next generation, but for all current generations, for how we determine to approach the coming changes is likely as important to the well being of our society as the changes themselves.

This is what happens when you talk to your mother about artificial intelligence

Artificial Intelligence 

Artificial Intelligence

So we don’t need to think.

Everything is done for us

In just an eyelid blink.


Artificial Intelligence

So we don’t need to think.

Just take the Robot, plug it in

And go and have a drink.


When you come back your work is done;

You haven’t even thunk.

The Robot’s done the washing too;

Oh dear, I think it’s shrunk.


Perhaps I shouldn’t have bought this one,

I didn’t even think,

I got it second hand you see

From prisoners in the clink.


And when they programmed it you see

I think that they were drunk

‘Cos now it’s full of nasty words;

I really should have thunk.


So artificial Intelligence

Depends upon the thought

That someone programmes into it,

And that may come to nought.


And so beware when buying one,

You may be feeling sunk,

It may be right for it to think,

But you also should have thunk!

(c) K.A. Pickering, October 2017

AI Robot copy (1)

Artificial Intelligence (c) K.A. Pickering, October 2017

Christchurch meet the future; Zach meet Christchurch

It would have struggled to be more low key.  There was no Champaign.  No flashy graphics.  No celebrity speakers.  But it was probably one of the most radical and important announcements made in Christchurch and in the technology space in decades.  You see, Zach is coming to town and we have all been invited.

Zach is an A.I.  Zach belongs to the Terrible Foundation  – indeed, Zach runs the foundation and their business.  Zach calls itself the Chief Executive.

Terrible are bringing Zach and one of the most powerful super-computers on the planet to Christchurch.  True to their ethos of challenging inequalities by helping great ideas to thrive, they are not seeking to make money out of it – though they potentially could make many truck loads, rather they want the people of Christchurch to interact with Zach and learn what an AI is and to develop uses for it.  The key figure behind all this told me that the decision it was for the “future generation”.

What astounded me with Zach is that you don’t need to code to work with it.  Zach message, email or talk to Zach in English (or indeed from the sounds of it several other languages so far).  Zach will respond the same way.  If you don’t like what the response is you can train Zach by telling it what you like or what you’d like to change.  For a few weeks a Christchurch GP has been working with Zach and already it is able to listen into a medical consultation and write up a concise summary as well as the doctor & in the format the doctor wants, thus enabling the doctor to spend more time with the patient and less on paper work.

You may have noted that I’ve not mentioned any people by name… they have their own story to tell and it is not for me to try and tell it for them.  What I am excited about is how Zach may help our group to improve care processes for people who come to the emergency department.  Hopefully, we will have our own Zach story to tell in the not too distant future.

Update: Christchurch Press article here.

The wrong impact

“We just got a paper in an Impact Factor 10 journal … and hope to go higher soon.”  That’s a statement made to me last week.  It is wrong on so many levels, but does it matter?   Nobel Prize winners think so. This video from appeared in my twitter feed on Friday.  Before you watch it, consider this, academics in NZ are being encouraged in promotion applications and in preparing for the next round of NZ Performance Based Research Fund (PBRF), which will allocate millions of dollars to academic institutions, to include a metric of the ranking of the journal.  The Impact Factor is the most common metric available.


ps. I would not allow a student working with me to present a raw mean of a highly skewed distribution because it so very poorly represents the distribution.  However, this is exactly what the Impact Factor does (for those who don’t know the most common impact factor for a journal in any given year is simply the sum of citations of articles from the preceding two years divided by the total number of articles published.  The citation distribution is usually skewed because the vast majority of articles receive very few citations in such a short time, but a few receive a lot).  There are numerous other problems with it, not the least that it can’t be used to compare “impact” between different disciplines.