Monthly Archives: August 2014

World Science Week: Where are we in the world?

It’s World Science Week.  So, where are we in the science world?  One measure showing our commitment to science is our expenditure on R&D.  If we compare ourselves to the other OECD countries, we see that we are right at the bottom of the pile at 1.27% of GDP and have recently been overtaken by Hungary.

OECD countries Research and Development expenditure as a function of Gross Domestic Product

OECD countries Research and Development expenditure as a function of Gross Domestic Product

You can explore this graph for yourself by clicking the link here.

In four weeks we will vote for a new government.  I blogged a link to party policies about health research last week. Labour have just released their policy and National are yet to. In the meantime, the Green party says we need another $1bn invested in R& D, which would add about 0.5% (based on a ~$200bn GDP) and United Future and Labour wish us to have at least the OECD average which means another $2bn or so investment.  In the meantime, UF, Greens, and Labour all want to re-establish tax credits for R&D which is intended to stimulate private investment in R&D.  If anyone knows the answer, I’d be interested to hear how many of the other OECD countries have R&D tax credits and what difference that has made to investment in R&D.

 

 

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Policy our lives depend on: Health research in election 2014

We all care about health – ours, our family’s, and even that of one or two politicians (perhaps). We also care that the 15 billion dollar annual health budget is spent on health care that works.  I contend that both these cares are only as good as the health research that underpins the treatments we receive.  Therefore, I have compiled what I could discover about health research policy from the policy documents available online of the political parties contending the current NZ general election. I have tried to focus on where health research in a particular area is promised or on health research infrastructure. In some places I’ve extracted from a more general science and/or innovation policy those policies I think likely to impact health research.  Obviously some parties are still releasing policy.  I invite them to send me any policies that they think relevant and I will update.  I think you will be surprised at what is missing in the list below.

The parties are in reverse alphabetical order.

United Future*

Health Policy: http://www.unitedfuture.org.nz/policy/health

  • Increase funding for health research to bring New Zealand’s funding up to at least the OECD average as a proportion of GDP;
  • Establish a national register for Type 1 Diabetes, a diabetes research fund, and increase funding for Type 2 Diabetes testing;
  • Make no change to the legal status of cannabis for medicinal use until a robust regulatory testing regime is developed that proves cannabis use causes minimal harm to an individual’s health
  • Introduce a sabbatical scheme that would allow health professionals to take a year out of work every five years to update their skills and knowledge;
  • Promote more research to address youth related health problems such as suicide, alcoholism, and bulimia.

Science Policy: http://www.unitedfuture.org.nz/policy/research-science-and-technology

Too long to put in detail, but policies such as “simplifying different funding mechanisms” and specifying biotech as one of half a dozen key research areas requiring focus are likely to impact on health research.

Health spokesperson (Associate Minister of Health): Peter Dunne MP peter.dunne@parliament.govt.nz

 

New Zealand First

Health Policy: http://nzfirst.org.nz/policy/health

  • Ensure an on-going commitment to the funding of health research, research institutes, and for training.

Science Policy: None

RS&T Portfolio holder: Tracey Martin MP tracey.martin@parliament.govt.nz

Health Portfolio holder: Barbara Steward MP   barbara.stewart@parliament.govt.nz

 

National

Health Policy: https://www.national.org.nz/news/features/health

No specific policy on any health research

Science Policy: None

Health spokesperson (Minister of Health): Tony Ryall tony.ryall@national.org.nz

Science spokesperson (Minister of Science and Innovation): Steven Joyce steven.joyce@national.org.nz

 

Maori Party

Policy: http://maoriparty.org/our-policies-kawanatanga/

  • We will support: … Roadshows to promote educational pathways in areas where Māori are under-represented – ie health science academies (Te Kura Pūtaiao Hauora) or science camps.

Science Policy: No specific policy but some comments in the policy above about research and development include establishing an investment fund for Māori Research and Development which may impact on health research.

Health or Science spokespeople: Unknown

Contact: Teururoa Flavell MP teururoa.flavell@parliament.govt.nz

 

Mana

Health Policy: http://mana.net.nz/policy/policy-health/

No policy specifically dealing with health research

Science Policy: None

Contact: Hone Harawira MP hone.harawira@parliament.govt.nz

 

Labour

Health Policy: http://campaign.labour.org.nz/full_health_policy

  • We need a health system that is based on evidence about what works – not fixated on manufactured targets or political slogans

Health spokesperson: Annette King annette.king@parliament.govt.nz

Science Policyhttps://www.labour.org.nz/sites/default/files/issues/science_and_innovation_policy.pdf (UPDATE – released 25 August)

  • Reinstate post-doctoral fellowships for recent PhD graduates (scaling up to %6m per year)
  • Prioritise an increase in our public science spend to link New Zealand to the OECD average over time
  • review and reform the National Science Challenges, on the basis of advice from the science community and building on the success of respected funding bodies such as the Marsden Fund

    provide integrated support for innovation across the Crown Research Institutes and tertiary institutions, and through private-sector research activities, and sectoral and regional initiatives

    review the criteria of the Performance Based Research Fund to ensure that a broad range of research success is recognised

    support research in universities, including through a continued commitment to Centres of Research Excellence

    encourage closer association between business and university commercialisation centres to ensure ‘discoveries’ within the universities are most effectively brought to market and have the best chance for success

    support and foster a collaborative university system, where each of our universities is enabled to focus on its areas of research and teaching strength.

  • support research in universities, including through:
    • a continued commitment to Centres of Research Excellence,
    • ensuring the sustainability of the Marsden Fund and other research funds
    • supporting the career pathways of graduates, to encourage our researchers to develop their careers and contribute to New Zealand.

Science Spokesperson: Moana Mackey MP moana.mackey@parliament.govt.nz

 

Internet

Health Policy: https://docs.google.com/document/d/1g4RY7Sh-vYZN1WAIx_A-AEZlYzNjMhzY81KnfKLMGp0/edit

Copyright and Open Research Policy: https://docs.google.com/document/d/1Le3rY0wlh9tJaBzpxK5xrpeWID-j5FmeE4dqONdQATE/edit

  • Mandate that all taxpayer-funded research be open access with the public able to freely access and re-use it.

Health or Science spokespeople: Unknown

Contact: hello@internet.org.nz

 

Green

Health Policy: No general health policy, but some on particular issues.

Update 25 Aug:  I have been informed that the Greens have a health policy on a different web site https://home.greens.org.nz/policy/health-policy.  Their election site http://www.greens.org has no health policy.

No policy specifically dealing with health research.

Green innovation Policy: https://www.greens.org.nz/policy/smarter-economy/smart-green-innovation

Some aspects of this policy may impact health research, in particular:

  • $1 billion of new government funding over three years for research and development to kick-start a transformational shift in how our economy creates wealth;
  • The Green Party will fund an additional 1,000 places at tertiary institutions for students of engineering, mathematics, computer science, and the physical sciences.

Health or Science spokespeople: Unknown

Contact greenparty@greens.org.nz

 

Conservatives

Health Policy: None

Science Policy: None

Health or Science spokespeople: Unknown

Contact: Office@conservativeparty.org.nz

 

ACT

Health Policy: http://www.act.org.nz/policies/health-0

No policy specifically dealing with health research

Science Policy: No science policy

Health or Science spokespeople: Unknown

Contact: info@act.org.nz

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*Disclaimer: I used to be a member of United Future and made submissions on the health and science policies in 2008. A few echoes of those submissions remain in the policies.

Cheesecake files: A stadium full

As we’ve been enjoying the World Cup and the Commonwealth Games my latest cheesecake appeared in print online. The topic once more is Kidney Attack biomarkers – those pesky little proteins in the urine that appear when your kidney is injured.  This time I have been getting stuck into some math (sorry) to try and understand what it is that affects when these biomarkers appear in the urine after injury.  I call this a biomarker time-course.  A “Pee Profile” may be a better term but it would never get past the editor.  What I care about is whether the type of biomarker and/or extent of injury, affects the pee profiles.

There are three basic types of biomarkers.  First are those that are filtered from the blood by the two million odd filters in the kidney.  Often they are then reabsorbed back into the blood in the little tubules where the pee is produced – that is, they don’t appear in the urine.  Think of it like a stadium with many entrances.  People (biomarkers) come in and sit down (are reabsorbed).  If, though, a section of the stadium has been fenced off because of broken seating from the previous game (the injury), then some of those entering the stadium may end up exiting it again (the pee biomarkers).  The numbers being reabsorbed and exiting will also depend on whether all the entrances are open – if some are closed then this will have a flow on affect on the rate of people leaving the stadium.

The second are preformed biomarkers.  If we change the analogy slightly, imagine these as people already in the stadium (if the analogy was accurate they would have been born there!).  If some terrible injury happens (like the 4th, 5th, 6th and 7th goals of a now famous football match) some of those people would get up and exit quickly.  The overall rate of exit would reflect on the extent of the injury.

The third, are induced biomarkers.  These are ones that don’t already exist, but are produced in response to an “injury.”  Instead of being biomarkers, let us think of the spectators as produces of these biomarkers and let noise be the biomarker.  There is some background noise of course, but when an “injury” (goal, gold medal performance etc) occurs there is a sudden increase in noise which slowly dies down.  Depending on the team and the number of supporters this will be softer or loader and will carry on for shorter or longer periods (Goooooooooooaaaaaaaaaaaa……lllllllllllll).

The upshot of it all were many coloured graphs and a step towards understanding how we may better make use of the various types of novel biomarkers of kidney injury that have been recently discovered.

PlosOneFigs

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Pickering, J. W., & Endre, Z. H. (2014). Acute kidney injury urinary biomarker time-courses. PloS One. doi:10.1371/journal.pone.0101288