Tag Archives: Obesity

Christchurch has breast cancer research hub

Guest post by: Kim Thomas, Communications Manager at the University of Otago, Christchurch

Research Radar UOC

A team of specialist cancer researchers have joined forces to focus on the impact of obesity on breast cancer.

The researchers all work at the University of Otago, Christchurch’s Mackenzie Cancer Research Group. The Group is headed by Canterbury District Health Board oncologist Professor Bridget Robinson, a breast cancer expert.

Researchers Associate Professor Gabi Dachs, Dr Margaret Currie and Dr Logan Walker have previously investigated various aspects of cancer but decided to team up and focus on the significant health issue of obesity.

Associate Professor Dachs says that international studies have shown breast cancer patients who were obese before or after diagnosis are less likely to survive than patients with normal BMI. Risk of dying from breast cancer increases by a third for every increment of 5kg/m2 in BMI.

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From left to right: A/Prof Gabi Dachs, Dr Margaret Currie, Dr Logan Walker

The three researchers are investigating different aspects of obesity and breast cancer:

  • Associate Professor Dachs is looking at molecular factors associated with obesity in cancer, particularly how fat cells communicate with cancer cells and negatively affect them.
  • Dr Margaret Currie is putting fat and breast cancer cells together to see how the fat cells make tumours more resistant to treatment. She suspects the fat cells provide ‘an extra energy hit’ to cancer cells by providing lipids, or fats, in addition to glucose.
  • Geneticist Dr Logan Walker will investigate whether the obesity-related gene responsible for the amylase enzyme in saliva (AMY1) contributes to breast cancer development. He will also explore the role of key genes that behave differently in breast tumours from obese women.

The researchers’ work is funded by the NZ Breast Cancer Foundation, the Cancer Society of New Zealand, the Canterbury and West Coast Division of the Cancer Society NZ, the Mackenzie Charitable Foundation and the University of Otago.

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A taste of success

Some recent successes of University of Otago Christchurch researchers:

Chlorine bleach key in disease?

Professor Tony Kettle from the Centre for Free Radical Research has won a prestigious Marsden Fund grant to better understand a ‘Jekyll and Hyde’ chemical with a role in heart disease, cancer, cystic fibrosis, and rheumatoid arthritis.

Professor Kettle will investigate chlorine bleach’s role in strengthening collagen by linking to form a resilient mesh. Without this mesh people can develop cataracts and an autoimmune disease that destroys the kidneys and causes the lungs to hemorrhage. However bleach can also have negative effects.

“Chlorine bleach should be viewed as a natural chemical with a Jekyll and Hyde personality. It helps us to fight infections and form strong connective tissue but also endangers our health during uncontrolled inflammation.”

Professor Kettle and his team will work with researchers from Vienna and Budapest on the project.

Improving the treatment and experience for dialysis patients

Chronic kidney disease is common, affecting about 500,000 New Zealanders. It is important because it increases chances of heart disease and death and may lead to needing treatment with dialysis or a kidney transplant. Dialysis therapy is a heavy and costly burden for patients and their families and the health system. However, there is a lack of reliable evidence to improve patient outcomes.

Dr Suetonia Palmer has just been awarded a prestigious Rutherford Discovery Fellowship valued at $800,000 over five years for research project called: “Improving evidence for decision-makers in chronic kidney disease.”

Dr Palmer’s research aims to to provide rigorous overviews of existing research and participant-led enquiry to provide better and more useable information for clinicians, consumers and policy-makers in the field of chronic kidney disease.

Recovering from food addiction

Professor Doug Sellman and his team from the National Addiction Centre have just been granted funding to trial a new treatment for those with obesity called Kia Akina.

“There is a serious need to develop new non-surgical ways of treating obesity because obesity-related diseases are expensive for New Zealand, traditional non-surgical methods are not working, and surgery is very costly,” says Professor Sellman.

Kia Akina uses a ‘food addiction’ approach to obesity. Professor Sellman says the project will test the feasibility, short-term effectiveness and participant satisfaction ofKia Akina within a primary health care setting.

If shown to be effective, Kia Akina will be developed as a non-commercial, low cost network for obesity recovery throughout New Zealand.

Innovation in Indigenous Health

Christchurch’s Maori/Indigenous Health Institute (MIHI) recently won the Australasian award for ‘innovation in Indigenous health curriculum implementation’ at the Leaders in Indigenous Medical Education (LIME) conference.

The LIME conference brings together all 20 medical schools throughout Australia and New Zealand, and hosts attendees from the United States and Canada.

Staff and students of the University of Otago, Christchurch, in Darwin at the Leaders in Indigenous Medical Education (LIME) conference

Staff and students of the University of Otago, Christchurch, in Darwin at the Leaders in Indigenous Medical Education (LIME) conference

MIHI director Suzanne Pitama says she and her team were thrilled to receive the award. As there is much collaboration between indigenous teaching teams at University of Otago’s Christchurch, Wellington and Dunedin campuses, the award recognises the innovation of all these teams.  It also recognised the systemic support within the University of Otago to prioritise indigenous health within the curriculum.

MIHI oversees the Maori health component of the medical curriculum at the University of Otago, Christchurch.

Award nominees are judged on how well their teaching programmes demonstrate their commitment and experience to understanding and furthering the health of Maori and Indigenous peoples.

The award has been presented for four years, says Pitama. MIHI also won it in the inaugural year.

A review panel of academic peers and members of indigenous medical doctors associations judge the award, Pitama says.

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This guest post was written by Kim Thomas,  Senior Communications Advisor, University of Otago, Christchurch, www.uoc.otago.ac.nz.

One third of New Zealanders addicted to food: fact or fiction?

Today’s Press Headlines read “Third of Kiwis ‘need to kick food addiction’”

The quote is attributed to Professor Doug Sellman, Director of the National Addiction Centre and is a call for more funding to support this group. My first reaction was “Give someone a hammer and everything looks like a nail.” Alas, I can’t leave it with my prejudices.

What evidence is there for food addiction and for 1/3rd of NZ’ers being addicted?

I searched the medical literature (PubMed) for any work relating to New Zealand and Food Addiction. I found one article from the NZ Medical Journal co-authored by Professor Sellman: Addictive overeating: lessons learned from medical students’ perceptions of Overeaters Anonymous. (N Z Med J. 2010 Mar 19;123(1311):15-21.). The research is a synthesis of the reports of 72 5th-year medical students who as part of their training attended a meeting of Overeaters Anonymous. The “results” are a series of quotations which pick up on some themes and includes the concept of the attendees talking about the concept of addiction.

A brief look at the review literature on PubMed revealed that the concept of “food addiction” is new and by no means an established addiction. One paper, How Prevalent is “Food Addiction”?  (Front Psychiatry. 2011; 2: 61), talks about how few tools there are to assess food addiction. One tool – a questionnaire –(the Yale Food Addiction Scale) has recently undergone some validation studies. In normal weight participants food addiction, according to this scale, was diagnosed in 8.8 and 11.4%. In one study of obese participants it was 25%. Interestingly there was very little correlation between diagnosis of food addiction and Body Mass Index in these studies. A second freely available review asks the question “Does Food Addiction Really Exist?” (Obesity Facts 2012 19;5(2):165-179). The authors note that in some individuals the underproduction of the hormone, leptin, “has a pronounced effect on the reward system, thus suggesting an indirect link between overeating and ‘chemical’ addiction.” Their major conclusions are:

“Because of the current rather limited evidence of the addictive behavior of specific food ingredients or additives, we currently conclude that food addiction can best be classified as a behavioral addiction at this time. However, because there is not sufficient (i.e., reliable and valid) data on its diagnostic criteria, we would not recommend adding ‘food addiction’ as a diagnostic entity in DSM-V” (the 5th edition of the American Psychiatric Society’s Diagnostic and Statistical Manual of Mental Disorders).

“We conclude that overeating may be viewed as food addiction in a small subgroup of obese individuals”.

Disclaimer: I have no expertise in Psychiatry or eating disorders.

Claimer: I can’t find any published research to support the contention that 1/3rd of New Zealanders are addicted to food.

Fat Rulz OK!

Dr Cat Pause is a Fat advocate.  For her “Obese” is a negative term, but Fat is good. She hit the headlines this week as the organiser of New Zealand’s first Fat Studies conference.  Listening to her interviews (see eg TVNZ interview) and reading some media around this event I detect two strains of argument

1. Fat people are discriminated against, therefore they need legal protection and a culture change in society.

2. Being Fat is not the detriment to health that most people think it is.

Regarding point 1, the language and emotion appear similar to other arguments from groups who believe they are discriminated against.  Over the last 40 years there has been tremendous change in NZ law to ensure no New Zealander is discriminated against on the basis of sex, sexual orientation, or race.  I thought the laws were broad enough to encompass other forms of discrimination including body size.  Apparently not according to Dr Pause.  Whether there is need for change is a matter for sociologists, psychologists, lawyers, politicians and anyone else who is interested to thrash out.  In the meantime I and most people I know would be happy to declare that it is absolutely wrong to put down someone simply because of their size; as Dr Pause said “Fat people deserve the same rights and dignity as non-Fat people.

It is the second claim of Dr Pause that which gives me some concern.  In a TVNZ interview she stated that science is not clear-cut about the relationship between fat and health.  When pushed on this claim she talked of studies linking weight and death: “quite often what we find is that studies will look at people who die and if anyone is fat in that sample they will say they died because of their weight.”  Frankly, I too would dismiss to the trashcan any studies that did this – that is bad science.  However, I don’t believe most studies do do this.  Rather they look at the rates of death and find that the rates are increased in the group with higher body mass.  That is, they are simply reporting an association rather than describing a cause.  Could her passion for fairness and justice be clouding her objectivity? Possibly. I see that in statements like “Fat people live in a world that openly hates them. They talk about solving the obesity epidemic.  That means getting rid of people like me.” Really?  I hope no one wants to get rid of you Dr Pause.  I expect many medical professionals are uneasy that her size may contribute negatively to her health – it is only part of her that they want to be rid of.

Could there be, though, something in the science throwing doubt on the claims that Fat is bad? The answer  is “yes, of course.”. Some call this the “Obesity Paradox.” Such is the nature of statistics and physiology that there are many exceptions to the rule that Fat is bad.  In a paper “Weight Science: Evaluating the Evidence for a Paradigm Shift (thanks David from The Atavatism blog for pointing this out) many of these exceptions are discussed.  The paper unfortunately seems to fall in the gap between being a meta-analysis and review, and perhaps fails to do justice to both genre.  Nevertheless, it raises several issues which throw doubt on the simplistic “all fat is bad” approach.  The authors claim that the, now common, belief that the current generation of children will live shorter lives than their parents because of obesity comes from an “opinion piece” in the New England Journal of Medicine which offered “no statistical evidence” to back it up (Full text here).  Good point, if true.  Looking at the NEJM article, though, statistics and a mathematical model for predicting life expectancy which takes into account obesity were used.  The conclusion was:

Our conservative estimate is that life expectancy at birth in the United States would be higher by 0.33 to 0.93 year for white males, 0.30 to 0.81 year for white females, 0.30 to 1.08 years for black males, and 0.21 to 0.73 year for black females if obesity did not exist (Figure 1). Assuming that current rates of death associated with obesity remain constant in this century, the overall negative effect of obesity on life expectancy in the United States is a reduction in life expectancy of one third to three fourths of a year.”

That there are many fat people who live long lives should not surprise us.  When people were arguing about smoking, every second smoker seemed to have an aunt who smoked a pack a day yet lived to 90.  Statistics are like that.  That fat may be protective in some circumstances should also not be surprising.  Diseases are a complex and full of surprises.  Having said that a brief look at the article in question showed me that it was disingenuous – it suggested that in a number of diseases obese people had greater longevity than thinner people.  I looked at the reference given for type II diabetes (see here) and found the abstracted stated that “Diabetic men and women of average weight had the lowest mortality. A J-shaped relative risk curve by weight category was found, with a poorer survival rate for those who were thin, overweight, or obese.”  Hmmm….not the impression given by the authors advocating a paradigm shift in thinking about obesity.  That paper is worth a read, but be cautious.

Unexplained findings should drive us to gain a better understanding of the disease processes and ultimately help us to deliver better health care.  I am less convinced that they should be used as a rallying cry by advocates for being Fat and Healthy.  Health is a relative term and there is no doubt that some Fat people are healthier than some non-fat people, but this does not mean they are as healthy as they can be.  Dr Pause calls for “not using weight as a proxy when talking about health.”  When faced with an individual I would expect a doctor to look at my health first, and my risk factors second.  Someone’s weight (very low or very high) may well be a risk factor for a disease…talking about it is not using it as a proxy.  Referring to statistics that test if weight is a contributing factor to a disease or poor outcome is no more using fat as a proxy as using ethnicity or sex or a comorbidity as a proxy.  They are simply risk factors which may be contributing to a disease process in an individual – they are flags for a doctor to carry out tests to eliminate or confirm the presence of certain diseases…without them the health system would either do nothing or crumble under the weight of “testing everyone for everything.”

In my own field of Acute Kidney Injury two recent epidemiological studies have shown that obesity is a risk factor for they disease after accounting for other factors (1,2). What is surprising, though, is in one study (note to reader…always take the epidemiology of just one study with a dose of caution) looking at patients with Acute Respiratory Distress Syndrome (ARDS) the body mass index was associated with decreased mortality.  However, AKI remained associated with increased mortality even after adjusting for body mass index.  I hope this kind of science will lead to further discovery of what may be protective measures in obese people with ARDS and be able to artificially apply those measures to all people.  This seems a better approach than taking one study like this and only one outcome from it (albeit an important one) and using it to say “Fat is OK.”

Dr Pause and her colleagues are advocating for a health centric rather than obese centric approach.  Seems sensible to me.  I would imagine that is exactly why most medical professionals do when they point out that some of someone’s health problems are due to their weight. What is becoming apparent, and may require changes in medical practice, is that the process of losing weight may be detrimental to health.  This is based on the theory that toxins stored in fat tissue are released when someone looses weight.  The rate of weight loss may be relevant here and whether is is kept off (a rare occurance apparently).  As it is the kidneys deal with toxins I’d like to see if dieting is a risk factor for Chronic Kidney Disease (obesity is).  Certainly, looking at the effects of dieting on health is a worthwhile research topic.  However, this begs the question – why store those toxins in the first place!  In the process of getting fat what damage has been done though the ingestion of large volumes of sugars? Is feeding our children poor nutrition resulting in some of them getting fat acceptable under any circumstance?  I think not.

Dr Pause appears to me to be in danger of cheery picking the science to support her social and political campaign.  Her statement that the “science is on her side” raised my “warning” antennae. It is the language of “me” verse “them” which I find distinctly unhelpful knowing that there are many scientists who will say “no it’s not.”  That some are prepared to challenge conventional wisdom in medicine is a good thing.  That they are prepared to use science to do so is even better.  However, it is beholden on all scientists to maintain objectivity .  This is not always easy and no doubt much harder when one feels discriminated against.